UniProt

UniProt is NAR Database No. 318.

Database Description

The Swiss-Prot, TrEMBL, and PIR protein database activities have united to form the Universal Protein Resource (UniProt), which provides a central resource on protein sequences and functional annotation with three database components, each addressing a key need in protein bioinformatics. The UniProt Knowledgebase (UniProtKB), comprising the manually annotated UniProtKB/Swiss-Prot section and the automatically annotated UniProtKB/TrEMBL section, is the preeminent storehouse of protein annotation. The extensive cross-references, functional and feature annotations, and literature-based evidence attribution enable scientists to analyze proteins and query across databases. The UniProt Reference Clusters (UniRef) speed similarity searches via sequence space compression by merging sequences that are 100% (UniRef100), 90% (UniRef90), or 50% (UniRef50) identical. Finally, the UniProt Archive (UniParc) stores all publicly available protein sequences, containing the history of sequence data with links to the source databases. The UniProt databases continue to grow in size and in availability of information. New download availability includes all major releases of UniProtKB, sequence collections by taxonomic division, and complete proteomes. A bibliography mapping service has been added, and an ID mapping service will be available soon.

Acknowledgements

UniProt is mainly supported by the National Institutes of Health (NIH) grant 1 U01 HG02712-01. Minor support for the EBI's involvement in UniProt comes from the two European Union contracts BioBabel (QLRT-2000-00981) and TEMBLOR (QLRI-2001-00015) and from the NIH grant 1R01HGO2273-01. Swiss-Prot activities at the SIB are supported by the Swiss Federal Government through the Federal Office of Education and Science. PIR activities are also supported by the National Science Foundation (NSF) grants DBI-0138188 and ITR-0205470.

References

1. Wu, C., Bairoch, A., Apweiler, R., Natale, D.A., Barker, W.C., Boeckmann, B., Ferro, S., Gasteiger, E., Huang, H., Lopez, R., Magrane, M., Martin, M.J., Mazumder, R., O'Donovan, C., Redaschi, N. (2006). The Universal Protein Resource (UniProt): an expanding universe of protein information. Nucleic Acids Res. 34: Database issue (in press).

Authors

Apweiler R.¹, Bairoch A.² and Wu C.H.^3,4

¹ EMBL Outstation - The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
²Swiss Institute of Bioinformatics and Department of Structural Biology and Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
³Department of Biochemistry and Molecular Biology, and ⁴Protein Information Resource, Georgetown University Medical Center, Suite 1200, 3300 Whitehaven Street NW, Washington, DC 20007, USA

External Links

• UniProt homepage
• UniProt abstract in the NAR 2006 Database Issue

Contact Email

• apweiler@ebi.ac.uk

UniProt is NAR Web Server Collection No. 810.

Web Server Description

UniProt (Universal Protein Resource) is the world's most comprehensive catalog of information on proteins. It is a central repository of protein sequence and function created by joining the information contained in Swiss-Prot, TrEMBL, and PIR.

External Links

• UniProt
• UniProt in PubMed (PMID:15588483)

Contact Email

• EMAIL: Missing!

Search for "UniProt" in:

Categories: NARDatabase | NARDatabase:Protein sequence databases | NARDatabase:General sequence databases | NARWebserver | NARWebserver:Protein | NARWebserver:Sequence Data | Articles also in Wikipedia | SRS database