SNP@Domain

From MetaBase

SNP@Domain is a web resource to identify SNPs within human protein domains.

Contents 1 Database Description 2 Authors 3 External Links 4 References

[edit] Database Description

The single nucleotide polymorphisms (SNPs) in conserved protein regions have been thought to be strong candidates that alter protein functions. Thus, we have developed SNP@Domain, a web resource, to identify SNPs within human protein domains.

We annotated SNPs from dbSNP with protein structure-based as well as sequence-based domains:

1. structure-based using SCOP and
2. sequence-based using Pfam.

This was done to avoid bias towards a specific domain assignment methodology.

Users can investigate SNPs within protein domains with 2D and 3D maps. We expect this visual annotation of SNPs within protein domains will help scientists select and interpret SNPs associated with diseases. A web interface for the SNP@Domain is freely available at http://snpnavigator.net/ and from http://bioportal.net/.

[edit] Authors

• Areum Han
• Hyo Jin Kang
• Yoobok Cho,
• Sunghoon Lee
• Young Joo Kim
• Sungsam Gong

[edit] External Links

• The SNP@Domain homepage

[edit] References

1. Pubmed
2. BioMed central