PINT

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Text from the NAR 2007 Database Issue (Database Summaries) by permission of Oxford University Press.

PINT is NAR Database No. 854.

Contents

Database Description

The first release of Protein-protein Interactions Thermodynamic Database (PINT) contains more than 1500 data of several thermodynamic parameters along with sequence and structural information, experimental conditions and literature information. Each entry contains numerical data for the free energy change, dissociation constant, association constant, enthalpy change, heat capacity change and so on of the interacting proteins upon binding, which are important for understanding the mechanism of protein-protein interactions. PINT also includes the name and source of the proteins involved in binding, their Protein Information Resource, SWISS-PROT and Protein Data Bank (PDB) codes, secondary structure and solvent accessibility of residues at mutant positions, measuring methods, experimental conditions, such as buffers, ions and additives, and literature information. A WWW interface facilitates users to search database on various conditions, feasibility to select the terms for output and different sorting options. Further, PINT is cross-linked with other related databases, PIR, SWISS-PROT, PDB and NCBI PUBMED literature database. The database is freely available at http://www.bioinfodatabase.com/pint/index.html

Authors

Shaji Kumar M.D.1 and Gromiha M.M.2

1Department of Biochemical Engineering and Science, Kyushu Institute of Technology, Iizuka 820-8502, Fukuoka, Japan
2Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), AIST Tokyo Waterfront Bio-IT Research Building, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan


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