PARPs Database

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PARPs Database: A LIMS systems for protein-protein interaction data mining or Laboratory Information management system

Contents 1 Database Description 1.1 Background 1.2 Description 1.3 Conclusions 2 Authors 3 References 4 External Links

[edit] Database Description

[edit] Background

In the apost-genomea era, mass spectrometry (MS) has become an important method for the analysis of proteins and the rapid advancement of this technique, in combination with other proteomics methods, results in an increasing amount of proteome data. This data must be archived and analysed using specialized bioinformatics tools.

[edit] Description

We herein describe aPARPs database,a a data analysis and management pipeline for liquid chromatography tandem mass spectrometry (LC-MS/MS) proteomics. PARPs database is a web-based tool whose features include experiment annotation, protein database searching, protein sequence management, as well as data-mining of the peptides and proteins identified.

[edit] Conclusions

Using this pipeline, we have successfully identified several interactions of biological significance between PARP-1 and other proteins, namely RFC-1, 2, 3, 4 and 5.

[edit] Authors

Droit A, Hunter JM, Rouleau M, Ethier C, Picard-Cloutier A, Bourgais D, Poirier GG.

[edit] References

• PMID 18093328

[edit] External Links

• http://www.biomedcentral.com/1471-2105/8/483