P53 mutation DB

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p53 mutation database list of somatic and germline mutations found in human cancer

Contents 1 Database Description 2 Authors 2.1 Contact Email 3 External Links 4 Publications

[edit] Database Description

Between 50,000 and 60,000 mutations in various genes associated with a wide variety of diseases have been reported. Reporting, storing and analyzing these data will be an important challenge in the future, as these databases will provide invaluable information for both clinical medicine and basic science. Locus-specific databases have been developed to exploit this huge volume of data. The p53 mutation database is a paradigm, as it constitutes the largest collection of mutations (28,000) reported in 150 cancer types. This database is an invaluable tool for molecular epidemiology and structural studies of the p53 protein.

[edit] Authors

1. Thierry Soussi, PhD
2. Linn Hjortsberg, PhD
3. Dallil Hamroun, PhD
4. Mireille Claustres, MD, PhD
5. Christophe Béroud, PhD

[edit] Contact Email

Thierry Soussi

[edit] External Links

• http://p53.free.fr

[edit] Publications

1. Soussi T, Ishioka C, Claustres M, Beroud C (2006) Locus-specific mutation databases: pitfalls and good practice based on the p53 experience. Nat Rev Cancer 6: 83-90.
2. Beroud C, Soussi T (2003) The UMD-p53 database: new mutations and analysis tools. Hum Mutat 21: 176-181.
3. Soussi T, Beroud C (2001) Assessing TP53 status in human tumours to evaluate clinical outcome. Nat Rev Cancer 1: 233-240.
4. a special issue of the journal "Human Mutation" devoted to p53 mutations in human cancer http://www3.interscience.wiley.com/journal/103020637/issue