InterPare

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Contents 1 Database Description 2 Authors 3 External Links 4 Contact Email 5 Paper

[edit] Database Description

InterPare is a large-scale protein domain interaction interface database http://interpare.net. It contains both inter-chain (between chains) interfaces and intra-chain (within chain) interfaces.

InterPare uses three methods to detect interfaces:

1. the geometric distance method for checking the distance between atoms that belong to different domains,
2. Accessible Surface Area (ASA), a method for detecting the buried region of a protein that is detached from a solvent when forming multimers or complexes, and
3. the Voronoi diagram, a computational geometry method that uses a mathematical definition of interface regions.

InterPare includes visualization tools to display protein interior, surface, and interaction interfaces. It also provides statistics such as the amino acid propensities of queried protein according to its interior, surface, and interface region. The atom coordinates that belong to interface, surface, and interior regions can be downloaded from the website.

[edit] Authors

Gong S, Park C, Choi H, Ko J, Jang I, Lee J, Bolser DM, Oh D, Kim DS, Bhak J.

[edit] External Links

• InterPare web page
• Manuscript
  • PubMed
  • BMC bioinformatics

[edit] Contact Email

[edit] Paper