DSD
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- Galperin MY. The Molecular Biology Database Collection: 2007 update. Nucl. Acids Res. 2007. 35: D3-D4; doi:10.1093/nar/gkl1008. http://nar.oxfordjournals.org/cgi/content/abstract/35/suppl_1/D3
DSD is NAR Database No. 892.
Contents |
Database Description
Dehydrogenase enzymes belong to the oxidoreductase class and utilise the coenzymes NAD and NADP. Stereo-selectivity is focused on the C4 hydrogen atoms of the nicotinamide ring of NAD(P). Depending upon which hydrogen is transferred at the C4 location, the enzyme is designated as A or B stereospecific. The Dehydrogenase Stereospecificity Database v1.0 (DSD) provides a compilation of enzyme stereochemical data, as sourced from the primary literature, in the form of a web-accessible database. There are two search engines, a menu driven search and a BLAST search. The entries are also linked to several external databases, including the NCBI and the Protein Data Bank, providing wide background information. The database is freely available online at: http://www.jenner.ac.uk/DSD/DSD is a unique compilation available on-line for the first time which provides a key resource for the comparative analysis of reductase hydrogen transfer stereospecificity. As databases increasingly form the backbone of science, largely complete databases such as DSD, are a vital addition.
Acknowledgements
Initial funding for DSD was provided by GlaxoSmithkline, BBSRC, MRC, and the UK Department of Health.
References
- C.P. Toseland, H.M. McSparron, and D.R. Flower (2005) DSD: An integrated, web-accessible database of dehydrogenase enzyme stereospecificities. BMC Bioinformatics, in press.
Authors
Toseland C.P., McSparron H.M. and Flower D.R.
- The Jenner Institute, University of Oxford, High Street, Compton, Berkshire, UK, RG20 7NN
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