CYGD - Comprehensive Yeast Genome Database

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Text from the NAR 2007 Database Issue (Database Summaries) by permission of Oxford University Press.

CYGD - Comprehensive Yeast Genome Database is NAR Database No. 441.

Contents

Database Description

One of the milestones of genome research was the determination of the sequence of the whole genome of the well-studied model eukaryote, the budding yeast Saccharomyces cerevisiae. Goal of this project was the sequencing of the entire nuclear genome of the commonly used laboratory strain S288C. The project started in 1989 and finished in spring 1996. More than 100 laboratories from Europe, USA, Canada and Japan took part of the joined effort.</p>

The MIPS Comprehensive Yeast Genome Database aims to present information on the genomic structure of Saccharomyces cerevisiae. CYGD presents itself as a knowledge base organized according to the genomic structure. <P>The data are shown for different abstraction levels of the genome. Update reports, graphical displays, and summary tables are provided for the entire genome, or alternatively, for one of the nuclear chromosomes or the mitochondrial genome (tabular, graphically). In particular, MIPS offers detailed genetic, biochemical, and cell biological information for all individual elements of the genomic structure, such as open reading frames (access ORFs via search tools using gene name aliases or text strings, or ORF listings regarding chromosome structure, or common attributes, such as function). Just as well, genetic, biochemical, and cell biological data are supplied for RNA genes and various DNA elements (e.g. centromers, or upstream activation sequences). Another means of data retrieval is available via browsing tables and graphics, reviews , or catalogues regarding a particular yeast topic.

A major part of this information gets extracted by manual annotation from the yeast literature, and results of the systematic functional analysis projects as well as cross-references to other in-house or external databases (NCBI, PIR, PEDANT, EMBL] provide complementary material. In addition information and links to related ascomycetous species are added as far as genomic information is available.

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